L1000CDS2: LINCS L1000 characteristic direction signatures search engine
نویسندگان
چکیده
منابع مشابه
LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures
For the Library of Integrated Network-based Cellular Signatures (LINCS) project many gene expression signatures using the L1000 technology have been produced. The L1000 technology is a cost-effective method to profile gene expression in large scale. LINCS Canvas Browser (LCB) is an interactive HTML5 web-based software application that facilitates querying, browsing and interrogating many of the...
متن کاملCompound signature detection on LINCS L1000 big data.
The Library of Integrated Network-based Cellular Signatures (LINCS) L1000 big data provide gene expression profiles induced by over 10 000 compounds, shRNAs, and kinase inhibitors using the L1000 platform. We developed csNMF, a systematic compound signature discovery pipeline covering from raw L1000 data processing to drug screening and mechanism generation. The csNMF pipeline demonstrated bett...
متن کاملSystematic Quality Control Analysis of LINCS Data
The Library of Integrated Cellular Signatures (LINCS) project provides comprehensive transcriptome profiling of human cell lines before and after chemical and genetic perturbations. Its L1000 platform utilizes 978 landmark genes to infer the transcript levels of 14,292 genes computationally. Here we conducted the L1000 data quality control analysis by using MCF7, PC3, and A375 cell lines as rep...
متن کاملL1000FWD: Fireworks visualization of drug-induced transcriptomic signatures.
Motivation As part of the NIH Library of Integrated Network-based Cellular Signatures (LINCS) program, hundreds of thousands of transcriptomic signatures were generated with the L1000 technology, profiling the response of human cell lines to over 20,000 small molecule compounds. This effort is a promising approach toward revealing the mechanisms-of-action (MOA) for marketed drugs and other less...
متن کاملSearch Direction ∗
A tractable model of pricing under directed search is proposed and integrated with a position auction for better slots (which rationalizes the consumer search order). Search is always inefficiently low because firms price out further exploration. Equilibrium product prices are such that the marginal consumer’s surplus decreases in the order of search. Consumers always find it optimal to follow ...
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ژورنال
عنوان ژورنال: npj Systems Biology and Applications
سال: 2016
ISSN: 2056-7189
DOI: 10.1038/npjsba.2016.15